An experimental drug that changes the way cells burn fuel helped obese mice lose body fat and, at higher doses, partially improved how their bodies handled sugar, according to a new study from the University of Alberta in Canada. The findings suggest a potential new direction for future obesity treatments that would work by rewiring metabolism rather than simply cutting appetite.The research, Targeting Metabolic Dysregulation in Obesity: The Interplay Between Pyruvate Dehydrogenase and Weight