Simple, drug-free therapies may be the most powerful way to ease knee arthritis pain. Credit: Shutterstock A new large-scale analysis has identified knee braces, water therapy, and exercise as the most effective non-drug options for managing knee osteoarthritis. The findings come from a meta-analysis published in the open-access journal PLOS One . Knee osteoarthritis (KOA) is a widespread and often disabling condition that affects millions of older adults. It leads to ongoing pain and stiffness