Chinese Academy of Sciences Mar 3 2025 Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect. This metabolic shift is essential for tumor growth, supplying energy, metabolites, and maintaining redox balance. The pyruvate dehydrogenase complex (PDC) plays a pivotal role in linking glycolysis to the tricarboxylic acid (TCA) cycle, but the mechanisms regulating PDC activity—especially through post-translational modifications like