Elsevier Jun 30 2026 Reviewed A novel study has found that obesity is associated with a distinct molecular program driving the transition from early-stage, premalignant breast lesions to invasive breast cancer. Rather than simply showing increased activation of classical invasive pathways, tumors from obese patients exhibited a distinct stress-adaptive phenotype. The findings from the study in The American Journal of Pathology , published by Elsevier, suggest that metabolic health could be an