Chinese Academy of Sciences Mar 3 2025 Pyroptosis, a highly inflammatory type of programmed cell death, has garnered attention for its potential in cancer treatment. Characterized by cell swelling and the formation of "bubble" structures, pyroptosis is closely linked to the dynamics of the endoplasmic reticulum (ER). Despite growing interest, the precise mechanisms by which the ER triggers pyroptosis remain poorly understood, and the development of effective small molecules to induce this form