By Hugo Francisco de Souza Reviewed by Danielle Ellis, B.Sc. Nov 4 2024 New research indicates that an acute exercise session may improve isolated muscle insulin resistance in carriers of a TBC1D4 nonsense mutation , a variant linked to hyperinsulinaemia and elevated type 2 diabetes risk. Study: Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise . Image Credit: PeopleImages.com - Yuri A/Shutterstock.com