Optimized costimulatory domains boost tumor killing in CAR NK cells

Raluca Maniță

São Paulo Research Foundation (FAPESP) Feb 20 2026 Researchers at the Ribeirão Preto Blood Center and the Center for Cell-Based Therapy (CTC) conducted a study using the NK-92 cell line to test new models of chimeric antigen receptors (CARs) with specific costimulatory domains, such as 2B4 and DAP12. The tests showed that these components helped make the cells "ready to attack," thereby increasing their ability to destroy tumors. The results were published in the journal  Frontiers in

Optimized costimulatory domains boost tumor killing in CAR NK cells https://www.news-medical.net - 20.02.2026 05:49

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Optimized costimulatory domains boost tumor killing in CAR NK cells https://www.news-medical.net - 20.02.2026 05:49