Brigham and Women's Hospital Nov 21 2024 Findings from a Mass General Brigham-led study that has followed participants since before birth may offer clues about the origins of Alzheimer's disease. Key takeaways: Stress-related immune activity during the late second to early third trimester of pregnancy can have long-term sex-dependent effects on offspring memory circuitry, function, and decline that potentially increase vulnerability for memory disorders, such as Alzheimer's disease, after