By Tarun Sai Lomte Reviewed by Susha Cheriyedath, M.Sc. Mar 12 2026 A new study reveals how age-related microbiome shifts can disrupt gut–brain signaling, uncovering a microbial pathway that may accelerate memory decline during aging. Study: Intestinal interoceptive dysfunction drives age-associated cognitive decline . Image Credit: Toey Andante / Shutterstock In a recent study published in the journal  Nature , researchers identified in mice a microbiome –gut–brain pathway in which impaired