Study reveals the first direct saliva biomarkers of sleep loss

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American Chemical Society Jun 4 2026 Sleep loss dulls alertness and coordination, and it can produce effects similar to severe intoxication, making actions like driving incredibly risky. But there's no clinical test for determining when someone is dangerously sleep deprived. Now, researchers report a step toward a non-invasive test for sleep deprivation in ACS'  Journal of Proteome Research . In a study of 20 men, they identified molecular differences in saliva after a full night's rest and 24

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