Frontiers Apr 10 2026 When you choose a diet version of your favorite fizzy drink, you consume non-nutritive sweeteners, which taste sweet but - unlike sugar - contain no calories. But health organizations are starting to raise concerns about the potential long-term impacts of these sweeteners, suggesting they could interfere with energy metabolism and increase the eventual risk of diabetes or cardiovascular disease. Now a new study in mice indicates that the popular sweeteners sucralose and