By Vijay Kumar Malesu Reviewed by Susha Cheriyedath, M.Sc. Feb 19 2026 Emerging evidence suggests that microbial metabolites not only regulate endogenous GLP-1 secretion but may also influence therapeutic response to GLP-1 receptor agonists, raising the prospect of microbiome-guided treatment strategies in obesity and type 2 diabetes. Study: GLP-1 agonists and the gut microbiome: A bidirectional relationship . Image Credit: Matt Fowler KC / Shutterstock In a recent review published in the