By Dr. Sanchari Sinha Dutta, Ph.D. Reviewed by Lauren Hardaker Sep 3 2025 New real-world data confirm the RSV vaccine offers strong protection for older adults across two winters, but highlight weaker responses in those with compromised immunity and cardiovascular disease. Study: RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons . Image credit: Ground Picture/Shutterstock.com A large-scale multicenter study published in JAMA revealed that