American Heart Association Jan 21 2026 Following a five-year upward trend likely impacted by the COVID pandemic, the number of heart disease and stroke deaths has declined, yet, heart disease and stroke still kill more people in the U.S. each year than any other cause, according to data reported in the  2026 Heart Disease and Stroke Statistics: A Report of U.S. and Global Data From the American Heart Association . Together, heart disease (22% of U.S. deaths) - the leading cause of death for

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