Developing brain cells routinely repair severe DNA damage during migration
DNA
Kyoto University Jun 17 2026 Newborn nerve cells must squeeze through crowded, narrow spaces-through dense tissue, past other cells, between fibers-to reach the areas where they form neural circuits in the brain cortex. In a new study published in Nature , researchers at Kyoto University's Institute for Integrated Cell-Material Sciences (WPI-iCeMS) and their collaborators report that this journey causes widespread DNA damage in neurons, resulting in double-strand breaks where both strands of
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