Discovery of gene silencer offers hope for autosomal dominant leukodystrophy
DNA
University of Pittsburgh Feb 13 2025 A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene "silencer" that resides in junk DNA is directly sparing people from a devastating and fatal progressive neurological disease. The discovery, published in Nature Communications , explains why not all people with the genetic mutation develop the disease – called autosomal dominant leukodystrophy (ADLD) – and has significant implications for
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