Epigenetic silencing of BEND4 unveils new path for PDAC treatment
DNA
Higher Education Press Nov 7 2024 A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM inhibitors in pancreatic cancer treatment. This innovative research provides a groundbreaking approach to targeting a tumor suppressor gene, BEND4, which is frequently methylated and silenced in pancreatic cancer. The study delves into the role of BEND4 in DNA damage
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