New compounds identified as inhibitors of DNA topoisomerase 1
DNA
University of Seville Apr 29 2025 Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published in the journal Proceedings of the National Academy of Sciences of the United States of America ,
din zilele anterioare