New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies
DNA
University of Bologna Aug 8 2024 A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells. The results - published in the journal Science Advances - could lead to significant advances in the development of new cancer treatments. One of the most important functions of topoisomerase I is the regulation of
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