NKAPL identified as a tumor suppressor and therapeutic target in NSCLC
DNA
Chinese Academy of Sciences Jul 29 2025 Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases and is often diagnosed at advanced stages, limiting treatment options. While genetic and epigenetic alterations are known contributors to its pathogenesis, DNA methylation-based biomarkers are increasingly recognized for their potential in early detection and prognosis. The NF-κB signaling pathway plays a pivotal role in cancer proliferation and immune evasion. Despite its
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