Study identifies DNA collisions driving genetic changes in cancer
DNA
University of Chicago Medical Center Nov 20 2024 Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication. Understanding the specific type of DNA damage that leads to
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