Impact Journals LLC Aug 27 2024 A new editorial was published in Oncotarget's Volume 15 on July 10, 2024, entitled, "Genotype matters: Personalized screening recommendations for germline CHEK2 variants." Recognized as a moderate-risk gene, CHEK2-; responsible for encoding the CHK2 protein, which plays a crucial role in the repair of DNA double-strand breaks-; is associated with a 20–40% lifetime risk of breast cancer (BC) by age 85. While CHEK2 pathogenic variants (PVs) were previously linked

Tag-uri: DNA