Boston University School of Medicine Sep 4 2025 Cardiovascular disease (CVD) remains the leading cause of death and disability for adults in the U.S. Recent projections from the American Heart Association suggest that by 2050, more than 45 million American adults will have clinical CVD and more than 184 million will have hypertension. As a result, inflation-adjusted direct health care costs related to CVD risk factors are projected to triple between 2020 and 2050, to $1.34 trillion annually,

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