University of Colorado School of Medicine Nov 20 2025 Public interest in drugs known as glucagon-like peptide-1 receptor agonists, also called GLP-1 RAs, has surged in recent years, with popular types like semaglutide (sold under brand names like Ozempic and Wegovy) becoming known for their weight-loss effects. These drugs originated as treatments for patients with type 2 diabetes , and although they are all classified as GLP-1 RAs, there are small, molecular differences between them. This