Mayo Clinic Nov 19 2025 Current genetic screening guidelines fail to identify most people with an inherited condition known as familial hypercholesterolemia that can cause dangerously high cholesterol and early heart disease, a Mayo Clinic study found.  The condition often passes silently through families for generations. It is highly treatable, yet people who remain undiagnosed are at greater risk for heart attacks and strokes.  Cardiovascular disease remains the leading cause of death in the