Ludwig-Maximilians-Universitaet Muenchen (LMU) Jul 11 2025 Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research. The γ-secretase enzyme is capable of cleaving more than 150 different membrane proteins. This includes the amyloid precursor protein, from which the deposits typical for Alzheimer's disease are formed, and the Notch1 protein, which plays an important role in cell communication and