Istituto di Ricerca in Biomedicina Oct 30 2025 One of the biggest challenges in cancer treatment is chemoresistance: tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often limited. The research team led by Arnab Ray Chaudhuri has now uncovered a mechanism by which BRCA2-deficient tumors develop this resistance. The proteins BRCA2 and FIGNL1 appear to have a different function than previously assumed. "These findings change