Chinese Academy of Sciences Oct 30 2025 Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas. While multimodal therapies have improved outcomes for low- and intermediate-risk patients, high-risk or metastatic cases still suffer poor survival rates below 30%. Existing treatments are often toxic and limited by drug resistance. Thiostrepton (TST), first isolated in the 1950s from Streptomyces azureus , has recently emerged as a