Chinese Academy of Sciences Nov 19 2025 Pertussis, or whooping cough, remains a highly contagious respiratory infection caused by Bordetella pertussis . Despite inclusion of pertussis vaccines in immunization programs since the 1970s, outbreaks have re-emerged globally due to waning immunity and bacterial evolution. In China, cases have dramatically increased since 2017, with more than 400,000 reported between January and July 2024. Meanwhile, resistance to macrolide antibiotics, once the first-

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