Two Americans, a French astronaut and a Russian cosmonaut said Sunday they are eager to blast off Wednesday on a flight to the International Space Station, replacing four crew members who cut their mission short and returned to Earth last month because of a medical issue. Crew 12 commander Jessica Meir, Jack Hathaway, European Space Agency astronaut Sophie Adenot and cosmonaut Andrey Fedyaev are scheduled for launch atop a Falcon 9 rocket at the Cape Canaveral Space Force Station at 6:01 a.m.