Researchers challenge the traditional understanding of how histone deacetylase inhibitors function

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Baylor College of Medicine Jun 5 2026 Researchers at Baylor College of Medicine and collaborating institutions are challenging the traditional understanding of how cancer drugs called histone deacetylase (HDAC) inhibitors function. For decades, scientists believed that these drugs blocked HDAC enzymes, which drive cancer development by altering how genes are turned on and off. The current study suggests that HDAC inhibitors do not necessarily rely solely on HDAC inhibition but also may affect

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