Targeting aggressive childhood leukemia with nanobody PROTACs

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University of Duisburg-Essen Oct 13 2025 Scientists at the University of Duisburg-Essen are researching new therapies for aggressive forms of childhood leukemia. For the first time, their approach tries to distinguish between two subtypes using so-called nanobody PROTACs. These attack diseased tissue while sparing healthy cells. The José Carreras Leukaemia Foundation is supporting the project, led by Prof. Dr. Shirley Knauer and Dr. Mike Blueggel from the Faculty of Biology, with 143,740 euros

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