Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign Oct 16 2025 In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch. Their knot-like structures afford these molecules high stability and diverse biological activities, making them a promising avenue for new therapeutics. To better unleash their clinical potential, a team from the Carl R. Woese Institute for Genomic Biology developed LassoESM, a new large