By Dr. Sanchari Sinha Dutta, Ph.D. Reviewed by Benedette Cuffari, M.Sc. Feb 4 2026 A landmark randomized trial shows that preparing the uterus using natural ovulation delivers the same chance of a healthy baby as hormone therapy, while sharply lowering the risk of dangerous pregnancy complications for mothers.  Study: Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial . Image Credit: Vectorium / Shutterstock.com