Institute of Science Tokyo Jan 21 2025 Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements. The structural integrity of bones has been attributed to bone remodeling-aa highly regulated process of bone formation and bone resorption (dissolving old and damaged bones), driven by osteoblast and osteoclast bone cells, respectively. An impaired bone remodeling process can result in fragile bones and eventually lead to detrimental