Case Western Reserve University Aug 5 2025 Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig's disease, is an incurable neurological disorder affecting motor neurons-nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing. Many ALS clinical trials, including those testing promising drugs, have fallen short of expectations-often because the extent of the disease can vary, and patients don't respond the same way to medications. But a new study led by