RNA steps up to protect the genome from DNA knots
Justitie
Hubrecht Institute Jun 13 2025 Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play important roles in turning genes on or off. But if not untangled in time, they can harm our genome. Now, researchers from the Knipscheer Group at the Hubrecht Institute, in collaboration with the Karolinska Institute, have uncovered a surprising mechanism that keeps
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