First Hospital of Jilin University Jun 19 2025 Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. While environmental and genetic factors contribute to HCC, increasing evidence points to epigenetic dysregulation as a central driver in hepatocarcinogenesis. This review article published in eGastroenterology  systematically explores the epigenetic mechanisms implicated in HCC pathogenesis, providing a comprehensive view