Trade negotiations between the US and the EU are entering a crucial stage. This column argues that, faced with a highly uncertain geopolitical situation, the EU should adopt vis-à-vis the US a negotiating approach compatible with its ambition of enhancing its political autonomy and economic resilience on the one hand, and building international alliances able to bring some order to the current economic chaos on the other hand. The authors identify “dos and don’ts” which, embedded in a