Alliance for Clinical Trials in Oncology Feb 2 2026 A national clinical trial led by the Alliance for Clinical Trials in Oncology has found that oxybutynin, a drug often used to treat overactive bladder symptoms, reduces hot flashes compared to the placebo in men receiving hormone therapy for prostate cancer. This primary analysis of Alliance A222001 is published in the Journal of Clinical Oncology. Oxybutynin demonstrated clear and clinically meaningful improvements in both hot flash frequency