Early clinical events predict disease progression in very early systemic sclerosis

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European Alliance of Associations for Rheumatology (EULAR) Jun 13 2025 The VEDOSS project has previously shown that 70% of patients with Raynaud's phenomenon and at least one red flag – systemic sclerosis (SSc)-specific antibodies, puffy fingers, or an SSc pattern on nailfold capillaroscopy –will fulfil the 2013 ACR/EULAR SSc criteria within 5 years. However, it is acknowledged that although essential for classification, fulfilment of the criteria does not necessarily reflect clinically

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