Elsevier Aug 19 2025 Cardiovascular disease is the leading cause of premature deaths in patients with bipolar disorder worldwide. In a novel study in young adults (aged 20-45) with bipolar disorder researchers were able to detect subtle (subclinical) abnormalities in how their heart muscle functions and pumps blood before the onset of heart failure by measuring peak systolic strain and myocardial work. The findings in Biological Psychiatry , published by Elsevier, point to new avenues for