University of Washington School of Medicine/UW Medicine Aug 1 2025 More than a decade ago, researchers found that an acute complication of type 1 diabetes, diabetic ketoacidosis (DKA), can be resolved with the hormone leptin, even in the absence of insulin.  An analysis published today in  The Journal of Clinical Investigation  explains how leptin affects the brain and how it might be used in future therapeutics.  DKA happens when the body is unable to make insulin and begins to break down fat