Sichuan University Mar 5 2026 Inflammatory osteolysis is a condition involving progressive bone tissue destruction and is observed in many well-known skeletal disorders, including rheumatoid arthritis, osteoporosis, and chronic apical periodontitis. This condition is driven by immune hyperactivation, sustained immune responses, and increased numbers of bone-degrading osteoclast cells, which together cause inflammation and weakening of affected bone tissue. Copper is a vital element for the