Juntendo University Mar 5 2026 Premature ovarian insufficiency (POI) is a clinically significant cause of infertility that affects between 1 to 3% of women of childbearing age. Symptoms include absent menses, low estrogen levels, and elevated follicle-stimulating hormone (FSH) levels. Although residual primordial follicles often remain in the ovaries of women with POI, these follicles frequently fail to develop spontaneously. Because FSH levels are already high, the follicles typically do not