Thomas Jefferson University May 25 2026 Targeting senescent cells with dasatinib-quercetin preserves disc structure and modulates degeneration-associated pathways in a mouse model. Intervertebral disc degeneration is a major cause of chronic back and neck pain, yet current treatments largely focus on symptom relief rather than preventing disease progression. A growing body of evidence suggests that cellular senescence, where cells lose proliferative capacity and secrete inflammatory factors,