Frontiers Journals Aug 1 2025 Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: senescence of liver cells accelerates fat accumulation, inflammation and fibrosis, while chronic steatosis in turn hastens hepatic decline. Up to 38 % of adults worldwide have MASLD, and prevalence, severity and mortality all rise with age. Ageing livers shrink by ~30%, clear lipids and glucose less efficiently, and regenerate more slowly after