By Vijay Kumar Malesu Reviewed by Susha Cheriyedath, M.Sc. Apr 29 2026 By reshaping how engineered immune cells use glucose, fats, and amino acids, researchers hope to help CAR-T therapy survive the hostile metabolism of solid tumors. Study: Metabolic reprogramming of CAR-T cells: a multi-pronged strategy to conquer the immunosuppressive tumor microenvironment . Image Credit: Corona Borealis Studio / Shutterstock In a recent review published in the journal  Cell Communication and Signaling ,