Bone Research Aug 13 2025 Osteogenesis imperfecta (OI) refers to a group of rare genetic bone disorders that results in the formation of fragile bones. In patients with OI, the matrix that makes up the bone has been found to be abnormal, leading to an increased risk of fractures. Genetic mutations affecting collagen matrix protein biosynthesis in osteoblasts, or bone-forming cells, have been implicated in OI. However, the role of osteocytes-mature bone cells derived from osteoblasts-in OI