Chinese Academy of Sciences Jul 7 2025 Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune diseases. One key component of these pathways is Lymphocyte Activation Gene 3 (LAG-3)-a classical immunosuppressive receptor that has long posed unresolved questions regarding its biological mechanisms. In a new study published on June 30 in Cell , researchers from the Institute of Biophysics of the Chinese Academy of Sciences, the